Totally, 7445 (3200 males) participants aged The detail of TLGS and its cardiovascular outcomes has been described Incidence of non-communicable diseases and their risk factors are evaluated. That assessed the prevalence of non-communicable diseases and the respective TLGS as a population based cohort initiated atĬonsists of two phases: the first phase of the TLGS was a cross-sectional study The Tehran Lipid and Glucose Study (TLGS), which is a population, based This study was carried out in the framework of Prevalence, relative risk and their PAFs resulted from different methods. Regression, and ranked the importance of risk factors according to their In the current study, weĮstimated the PAFs based on indirect methods and a direct method using logistic Of risk factors based on their PAFs is a key point that may be influenced byĪpplying different methods in calculation of PAF. Strategies that target certain risk factors at the community level 9 thus ranking the importance PAFs may aid policy makers in anticipating the potential impact of preventive The burden attributed to the CVD has been ranked third among the national In Iran, CVD is the first cause of death and Instance, they may yield a more than 100% sum of all existing PAFs, which isĪccordingly, the need for novel approaches of calculating PAF has been To the existing methodological challenges, PAF has been less applied as aĬommon public health measure to date because, most of the approaches that haveīeen declared for the calculation of PAF may yield unacceptable results. its relative risk, with its prevalence, PAF provides anĮstimation of the relation between risk factor and incidence of diseases at the Incidence would not occur if the factor were eliminated. Population attributable fraction (PAF) of that risk factor 1. General population attributed to a specific risk factor is defined as Proportion of incidence of a disease in a Population Attributable Fraction, Methods Risk Factor, Cardiovascular Disease, Relative Risk, This study provides evidence on the moreĮxpediency of direct method over indirect ways when individual data isĪvailable through a population-based cohort. Pattern of PAFs of risk factors was somehow different among differentĬonclusions: Estimating priorities of risk factors may differ inĭifferent methods for calculating PAF. The direct estimation attributed 80% and 86% of burden of CVDĮvents to conventional risk factors in men and women respectively. PAFs resulted from indirect estimations reached to more than 100% (around 200% Levin ’ s and Miettinen ’ s equations were applied to indirectlyĮstimate the PAFs and average PAF was directly derived from logistic regression (HR) and Odds ratio (OR) of conventional risk factors were calculated for CVDĮvents after ten yr of follow-up. Population-based cohort of Tehran Lipid and Glucose Study (TLGS). (3200 males and 4245 females aged ≥ 30 yr) without history of CVD were selected from the Our aim was toĮstimate the PAFs of CVD risk factors via direct, i.e. Of great importance in conducting preventive strategies. Of death worldwide and the estimation of accurate PAFs for CVD risk factors is Cardiovascular disease (CVD) is the first cause Most practical measures for estimating the burden of risk factors with someĬhallenges in its calculation. University of Medical Sciences, Tehran, Iranĭavood Khalili (MD, PhD), E-mail: : 11 AugustĢ014, Revised : 22 October 2014, Accepted : 08 November 2014, Availableīackground: Population Attributable Fraction (PAF) is one of the Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti Shahid Beheshti University of Medical Sciences, Tehran, IranĬommunity Medicine, School of medicine, Shahid Beheshti University of Medical Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Ministry of health and medical Education, Tehran, Iran Sciences and Center for Non-communicable disease Control, Deputy of Health, Sayyedeh Sara Azimi (MSc) a, Davood Khalili (MD, PhD) b*, Farzad Hadaegh (MD, PhD) b, Parvin Yavari (MD,PhD) c, Yadollah Mehrabi (PhD) d, Fereidoun Azizi (MD,Įpidemiology, School of Public Health, Shahid Beheshti University of Medical Copyright © Journal of Research in HealthĬalculating Population Attributable Fractionįor Cardiovascular Risk Factors Using Different Methods in a Population Based
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